Search on: DELTA-AMINOLEVULINATE SYNTHASE 
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Descriptor English:   5-Aminolevulinate Synthetase 
Descriptor Spanish:   5-aminolevulinato sintetasa 
Descriptor Portuguese:   5-Aminolevulinato Sintetase 
Synonyms English:   5 Aminolevulinate Synthase
5 Aminolevulinate Synthetase
5-Aminolevulinate Synthase
Acid Synthetase, Aminolevulinic
Acid Synthetase, delta-Aminolevulinic
Aminolevulinic Acid Synthetase
Synthase, 5-Aminolevulinate
Synthase, delta-Aminolevulinate
Synthetase, 5-Aminolevulinate
Synthetase, Aminolevulinic Acid
Synthetase, delta-Aminolevulinic Acid
delta Aminolevulinate Synthase
delta Aminolevulinic Acid Synthetase
delta-Aminolevulinate Synthase
delta-Aminolevulinic Acid Synthetase  
Tree Number:   D08.811.913.050.276
Definition English:   An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta-aminolevulinate. It is a pyridoxyal phosphate protein and the reaction occurs in mitochondria as the first step of the heme biosynthetic pathway. The enzyme is a key regulatory enzyme in heme biosynthesis. In liver feedback is inhibited by heme. EC 2.3.1.37. 
History Note English:   98(72) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   634 
Unique Identifier:   D000624 

Occurrence in VHL: 		 

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